MovDisordV3, Main, Exploration, bibRecord, 004B71

[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration

Identifieur interne : 004B71 ( Main/Exploration ); précédent : 004B70; suivant : 004B72

[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration

Auteurs : Walter Pirker [Autriche] ; Susanne Asenbaum [Autriche] ; Gerhard Bencsits [Autriche] ; Daniela Prayer [Autriche] ; Willibald Gerschlager [Autriche] ; Lüder Deecke [Autriche] ; Thomas Brücke [Autriche]

Source :

Movement disorders [ 0885-3185 ] ; 2000.

RBID : Pascal:01-0016454

Descripteurs français

Pascal (Inist)
- Ophtalmoplégie supranucléaire, Atrophie multisystématisée, Parkinson maladie, Dégénérescence, Cortex cérébral, Noyau gris central, Tomoscintigraphie, Photon, Neurone dopaminergique, Diagnostic différentiel, Etude comparative, Adulte.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Basal ganglion, Cerebral cortex, Comparative study, Degeneration, Differential diagnostic, Dopaminergic neuron, Emission tomography, Multiple system atrophy, Parkinson disease, Photon, Supranuclear ophthalmoplegia.

Abstract

Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects performing single photon emission computed tomography (SPECT) 20 hours after injection of [¹²³I]β-CIT. Overall striatal binding was significantly reduced in MSA (-51% of normal mean), PSP (-60%), CBD (-35%), and PD (-58%), without overlap with control values. Asymmetry of striatal β-CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen-caudate nucleus ratios in patients with PD, MSA, and PSP, but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [¹²³I]β-CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does not seem to be possible to differentiate these disorders from PD with this method.

Affiliations:

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Le document en format XML

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I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration</title>
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<series><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Basal ganglion</term>
<term>Cerebral cortex</term>
<term>Comparative study</term>
<term>Degeneration</term>
<term>Differential diagnostic</term>
<term>Dopaminergic neuron</term>
<term>Emission tomography</term>
<term>Multiple system atrophy</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Supranuclear ophthalmoplegia</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Ophtalmoplégie supranucléaire</term>
<term>Atrophie multisystématisée</term>
<term>Parkinson maladie</term>
<term>Dégénérescence</term>
<term>Cortex cérébral</term>
<term>Noyau gris central</term>
<term>Tomoscintigraphie</term>
<term>Photon</term>
<term>Neurone dopaminergique</term>
<term>Diagnostic différentiel</term>
<term>Etude comparative</term>
<term>Adulte</term>
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<front><div type="abstract" xml:lang="en">Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects performing single photon emission computed tomography (SPECT) 20 hours after injection of [<sup>123</sup>
I]β-CIT. Overall striatal binding was significantly reduced in MSA (-51% of normal mean), PSP (-60%), CBD (-35%), and PD (-58%), without overlap with control values. Asymmetry of striatal β-CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen-caudate nucleus ratios in patients with PD, MSA, and PSP, but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [<sup>123</sup>
I]β-CIT SPECT reliably enables the visualization of the presynaptic dopaminergic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does not seem to be possible to differentiate these disorders from PD with this method.</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
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<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Pirker, Walter" sort="Pirker, Walter" uniqKey="Pirker W" first="Walter" last="Pirker">Walter Pirker</name>
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<name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name>
<name sortKey="Asenbaum, Susanne" sort="Asenbaum, Susanne" uniqKey="Asenbaum S" first="Susanne" last="Asenbaum">Susanne Asenbaum</name>
<name sortKey="Bencsits, Gerhard" sort="Bencsits, Gerhard" uniqKey="Bencsits G" first="Gerhard" last="Bencsits">Gerhard Bencsits</name>
<name sortKey="Brucke, Thomas" sort="Brucke, Thomas" uniqKey="Brucke T" first="Thomas" last="Brücke">Thomas Brücke</name>
<name sortKey="Deecke, Luder" sort="Deecke, Luder" uniqKey="Deecke L" first="Lüder" last="Deecke">Lüder Deecke</name>
<name sortKey="Gerschlager, Willibald" sort="Gerschlager, Willibald" uniqKey="Gerschlager W" first="Willibald" last="Gerschlager">Willibald Gerschlager</name>
<name sortKey="Prayer, Daniela" sort="Prayer, Daniela" uniqKey="Prayer D" first="Daniela" last="Prayer">Daniela Prayer</name>
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</tree>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration

[123I]β-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri